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Home > Pharmacy News >Drug Alerts > HIV Antiviral Drugs and Heart Risk


27-10-2010. The Food and Drug Administration warned doctors and HIV patients that two antiviral drugs can cause dangerous heart rhythms when they are combined.


The agency says the combination of Roche's Invirase and Abbott Laboratories' Norvir can trigger irregular heartbeats, leading to fainting, lightheadedness and even death. The FDA is requiring the companies to add information about the risk to their drugs' warning labels and to distribute pamphlets to patients.

Patients with HIV generally cycle through combinations of medicines to control the virus, which attacks the immune system.


The FDA approved Invirase in 1995 to lower HIV levels in the blood. It is often combined with Norvir and similar antiviral medications to improve effectiveness.


"These heart conditions could potentially be life-threatening and we want to assure that health care providers and patients are adequately informed of the risks," said Dr. Edward Cox, office of FDA's office of antimicrobial products.



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